Fri Apr 29 2022

52 articles - From Saturday Apr 23 2022 to Friday Apr 29 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Efficacy and Safety of Dapagliflozin According to Frailty in Heart Failure With Reduced Ejection Fraction : A Post Hoc Analysis of the DAPA-HF Trial.

Dapagliflozin improved al outcomes examined, regardless of frailty status. However, the absolute reductions were larger in more frail patients. Primary funding source AstraZeneca.

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International Validation of the Canadian Syncope Risk Score : A Cohort Study.

This international external validation of the CSRS showed good performance in identifying patients at low risk for serious outcomes outside of Canada and superior performance compared with the OESIL score. However, clinician classification of syncope at ED discharge seems to explain much of the performance of the CSRS in this study. The clinical utility of the CSRS remains uncertain. Primary funding source Swiss National Science Foundation & Swiss Heart Foundation.

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Lancet

Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802/WJOG4607L): a multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial.

Interpretation To our knowledge, this study was the first phase 3 trial to show the benefits of segmentectomy versus lobectomy in overall survival of patients with small-peripheral NSCLC. The findings suggest that segmentectomy should be the standard surgical procedure for this population of patients. Funding National Cancer Center Research and the Ministry of Health, Labour, and Welfare of Japan.

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Subacromial balloon spacer for irreparable rotator cuff tears of the shoulder (START:REACTS): a group-sequential, double-blind, multicentre randomised controlled trial.

Interpretation In an efficient, adaptive trial design, our results favoured the debridement only group. We do not recommend the InSpace balloon for the treatment of irreparable rotator cuff tears. Funding Efficacy and Mechanism Evaluation Programme, a Medical Research Council and National Institute for Health and Care Research partnership.

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Topical imiquimod versus surgery for vulvar intraepithelial neoplasia: a multicentre, randomised, phase 3, non-inferiority trial.

There was no significant difference in HPV clearance, adverse events, and treatment satisfaction between study groups. Imiquimod is a safe, effective, and well accepted alternative to surgery for women with vHSIL and can be considered as first-line treatment. Austrian Science Fund and Austrian Gynaecological Oncology group.

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N Engl J Med

Nasal High-Flow Therapy during Neonatal Endotracheal Intubation.

Among infants undergoing endotracheal intubation at two Australian tertiary neonatal intensive care units, nasal high-flow therapy during the procedure improved the likelihood of successful intubation on the first attempt without physiological instability in the infant. (Funded by the National Health and Medical Research Council; Australian New Zealand Clinical Trials Registry number, ACTRN12618001498280.).

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Prefusion F Protein-Based Respiratory Syncytial Virus Immunization in Pregnancy.

RSVpreF vaccine elicited neutralizing antibody responses with efficient transplacental transfer and without evident safety concerns. (Funded by Pfizer; ClinicalTrials.gov number, NCT04032093.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Lancet

Acute glomerulonephritis.

In the last few years, substantial progress has been made in unravelling the underlying causes and pathogenetic mechanisms of glomerulonephritis and a causal approach to the classification of glomerulonephritis is now favoured over a pattern-based approach. As such, glomerulonephritis can be broadly classified as immune-complex glomerulonephritis (including infection-related glomerulonephritis, IgA nephropathy, lupus nephritis, and cryoglobulinaemic glomerulonephritis), anti-neutrophil cytoplasmic antibodies-associated (pauci-immune) glomerulonephritis, anti-glomerular basement membrane glomerulonephritis, C3 glomerulopathy, and monoclonal immunoglobulin-associated glomerulonephritis. We provide an overview of the clinical presentation, pathology, and the current therapeutic approach of the main representative disorders in the spectrum of glomerulonephritis.

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Disease-modifying anti-asthmatic drugs.

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Malaria in 2022: a year of opportunity.

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Offline: France and some lessons for a fairer society.

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N Engl J Med

Audio Interview: Communicating Covid-19 Science.

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Understanding Vaccine Safety and the Roles of the FDA and the CDC.

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Letters&Replies

Letters to the editors and authors’ replies

Lancet

Advanced endoscopy unit in Gaza: first year of activity.

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Choosing WHO's new Director for Gender, Equity, Diversity and Rights for Health.

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Expanding diagnostics for LMICs - Authors' reply.

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Expanding diagnostics for LMICs.

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Nociplastic pain is functional pain - Authors' reply.

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Nociplastic pain is functional pain.

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Responding to the humanitarian crisis of the war in Ukraine with lessons from COVID-19.

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Should peer reviewers be paid to review academic papers?

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The message on malaria is clear: progress has stalled.

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Transforming the UK's diagnostics agenda after COVID-19.

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N Engl J Med

Antibiotic Prophylaxis for Latent Rheumatic Heart Disease.

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Antibiotic Prophylaxis for Latent Rheumatic Heart Disease. Reply.

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CTLA-4 Blockade Resistance after Relatlimab and Nivolumab.

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Defective piRNA Processing and Azoospermia.

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Defective piRNA Processing and Azoospermia.

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Defective piRNA Processing and Azoospermia.

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Defective piRNA Processing and Azoospermia. Reply.

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New Equations for Estimating the GFR without Race.

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New Equations for Estimating the GFR without Race.

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New Equations for Estimating the GFR without Race.

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New Equations for Estimating the GFR without Race.

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New Equations for Estimating the GFR without Race. Reply.

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Others

all remaining publications eg case reports, images of the month, etc…

Ann Intern Med

Annals Graphic Medicine - Dr. Mom: Bedtime Hack.

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Professional Courtesy.

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Lancet

Medicare covers new Alzheimer's drug, but there is a catch.

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Picturing health: the burden of leprosy in eastern Indonesia.

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Research Focus: Protas.

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Subacromial balloon spacer for irreparable rotator cuff tears.

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The health-environment nexus: global negotiations at a crossroads.

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Topical imiquimod as first-line treatment for vulvar intraepithelial neoplasia.

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Transgender Ukrainians facing "exacerbated" challenges.

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When less is more in thoracic surgery.

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N Engl J Med

A Data Infrastructure for Clinical Trial Diversity.

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Case 13-2022: A 56-Year-Old Man with Myalgias, Fever, and Bradycardia.

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Expanding Accountable Care's Reach among Medicare Beneficiaries.

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Iris Atrophy in Sickle Cell Disease.

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Ocular Gonorrhea.

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Peers, Professionalism, and Improvement - Reframing the Quality Question.

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The E-Cigarette Flavor Debate - Promoting Adolescent and Adult Welfare.

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